what is sucralose


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what is sucralose

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Sucralose (TGS) is a new sweetener developed by Tate&Lyie and university of London and patented in 1976. Splenda is the only functional sweetener based on sucrose, originally branded Splenda, which is 600 times sweeter than sucrose. This sweetener has no energy, high sweetness, pure sweetness, high safety and other characteristics. It is one of the best functional sweeteners.

Sucralose or TGS CNS: 19.016; INS: 955), also known as Sucralose, sucrose or 4, 1, 6, -trichloro-4, 1, 6, -trideoxygalactose sucrose, English name: Sucralose. Sucralose is prepared from sucrose by chlorination. The molecular formula is C12H19Cl3O8 and the relative molecular weight is 397.64.

The basic information
Chinese name

Foreign names

1 Basic Information
2. Physical data
3 Storage Methods
4 Synthesis methods
5 Main Uses
6 System Id
7 Toxicological data
8 Chemical Data
9 Ecological Data
10 Properties
Fold to edit this section of basic information
Chinese name: sucralose

English name :Sucralose

Chinese nickname: sucralose

1, 6-dichloro-1, 6-dideoxy-beta-d-fructofuranosyl-4-chloro-4-deoxy-alpha-d-Galactopyranoside; 4, 1 ‘, 6 ‘- trichloro – 4, 1′, 6 ‘trideoxy – Pentagalactosucrose; 1, 6 – dichloro – 1, 6 – dideoxyhex – 4 – chloro – 4-2 – ulofuranosyl deoxyhexopyranoside

CAS no. : 56038-13-2

Molecular formula: C12H19Cl3O8

Molecular weight: 397.6335

Fold to edit this section of physical data
1. Properties: White to nearly white crystalline powder, actually odorless, non-hygroscopic. Density (g/mL,15ºC) : 1.357

3. Relative density: 1.66 (20ºC)

Melting point (decomposition) : 125ºC

Boiling point (ºC) : 104-107

Boiling point (ºC, 0.5mmHg) : undetermined

7. Refractive index: not determined

8. Flash point (°F) : undetermined

9. Specific optical rotation (ºC) : not determined

10. Spontaneous ignition point or ignition temperature (ºC) : not determined

11. Vapor pressure (kPa,25ºC) : not determined

12. Saturated vapor pressure (kPa,60ºC) : not determined

13. Heat of combustion (KJ/mol) : not determined

14. Critical temperature (ºC) : not determined

15. Critical pressure (KPa) : not determined

16. Logarithm value of the oil-water (octanol/water) partitioning coefficient: undetermined

17. Upper limit of explosion (%,V/V) : not determined

18. Lower limit of explosion (%,V/V) : not determined

19. Solubility: easily soluble in water, ethanol and methanol, slightly soluble in ether.

Collapseedit this section storage method
Food grade plastic bag and kraft paper bag. Store in a cool and dry place

Fold edit this section synthesis method
1. Using sucrose as raw material, sucralosucrose was obtained by triphenylmethylation (shielding three primary hydroxyl groups), acetylation (shielding five secondary hydroxyl groups), removal of triphenylmethyl, acetyl group migration, chlorination, deacetylation, etc.

There are three methods of preparation of sucralose: single ester method, enzyme-chemical method and group transfer method. The first two methods only protect a certain hydroxyl group, so the degree of substitution cannot be controlled during chlorination, and the resulting product is a mixture, especially the single-ester method may cause the decomposition of sucrose to yield fructose ester. However, the group migration method protects multiple hydroxyl groups at the beginning, so that the chlorination reaction tends to be oriented, and a relatively single product can be obtained without special separation technology, with the yield up to 36%.

Collapsible edit the main use of this section
Sucralose is an approved sweetener in China. Its sweetness is about 600 times that of sucrose, and its sweet taste is pure. Its sweet character and sweet quality are very similar to that of sucrose. In general food processing and storage process are very stable, water-soluble, suitable for all kinds of food processing. China’s regulations can be used for drinks, pickles, compound seasonings, wine, ice cream, cakes, biscuits, bread and many other fields.

Fold and edit the system number of this section
CAS no. : 56038-13-2

MDL number: MFCD03648615

EINECS no. : 259-952-2

RTECS number: LW5440140

BRN number: 3654410

Fold and edit this section of toxicology data
1. Toxicity: LD50 (mice, orally) 16g/kg (BW); (Rats, orally) 10g/kg (bw).

Fold to edit this section of chemical data
1, hydrophobic parameter calculation reference value (XlogP) : -1.5

2. Number of hydrogen bond donors: 5

3. Number of hydrogen bond receptors: 8

4. Number of rotatable bonds: 5

5. Number of tautomers:

6. Topological molecular polar surface area (TPSA) : 129

7. Heavy atoms: 23

8, surface charge: 0

9. Complexity: 405

10, isotope atomic number: 0

11. Determine the number of atomic structure centers: 9

12. Number of uncertain atomic structure centers: 0

13. Determine the number of chemical bond structure centers: 0

14. Number of uncertain bond structure centers: 0

15. Number of covalent bond units: 1

Fold to edit this section of ecological data
Do not allow undiluted or large quantities of products to come into contact with groundwater, waterways or sewage systems, and do not discharge materials into the surrounding environment without permission from the government.

Fold edit this section property features
Does not decompose if used and stored according to specifications and no known hazardous reactions

Safety information
Customs code: 2932999099
Danger class code: R36/37/38
Safety description: 26-37/39
RTECS number: LW5440140
Identifier of dangerous goods: Xi: Irritant;
Customs data
China Customs (2932999099)
Overview 2932999099. Other heterocyclic compounds containing only hetero atoms. VAT rate :17.0%. Rebate rate :13.0%. Supervision conditions: None. MFN tariff :6.5%. General tariff :20.0%
Other heterocyclic Compounds with Oxygen Hetero-Atom (s) only. VAT:17.0%. Tax Rebate Rate :13.0%.. MFN Trade-related: 6.5% General trade-related: 20.0%
Synthetic route
Synthesis route (9 in total)


Sucrose – 6-ethyl ester

~ 70%



Details > >
Upstream and downstream products
Upstream products (10 in total)


Sucrose – 6-ethyl ester


Trimethyl acetate


P-toluenesulfonic acid





Post time: Aug-04-2021